Despite that the above include what are generally known as STIs, sexually transmission of microbes is far from limited to the above list.

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Viral STIs include genital herpes, HIV/AIDS, and genital warts among others.

Parasitic STIs include trichomoniasis among others. While usually spread by sex, some STIs can also be spread by non-sexual contact with contaminated blood and tissues, breastfeeding, or during childbirth.

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The amount of contact with infective sources which causes infection varies with each pathogen but in all cases a disease may result from even light contact from fluid carriers like venereal fluids onto a mucous membrane.

This is one reason that the probability of transmitting many infections is far higher from sex than by more casual means of transmission, such as non-sexual contact—touching, hugging, shaking hands—but it is not the only reason.

In a disease, the infection leads to impaired or abnormal function.

In either case, the condition may not exhibit signs or symptoms.

STD may refer only to infections that are causing diseases, or it may be used more loosely as a synonym for STI.